Failure in protein import can lead to several cellular and tissue-level consequences:
Mislocalization: Proteins may fail to reach their functional destination, leading to impaired cellular function. Protein Aggregation: Accumulation of misfolded proteins can form aggregates, which are often toxic to cells. Cellular Stress: Improper protein import can trigger stress responses, such as the unfolded protein response (UPR) in the ER. Disease: Defects in protein import pathways are implicated in various diseases, including neurodegenerative disorders like Parkinson's and Alzheimer's.
