Several factors influence the effectiveness of temporal summation: - Frequency of Stimuli: Higher frequencies of presynaptic stimuli increase the likelihood of successful temporal summation. - Synaptic Strength: Stronger synapses, with more efficient neurotransmitter release and receptor binding, enhance temporal summation. - Refractory Period: The time during which a neuron is less responsive to additional stimuli can affect the temporal summation process. - Neurotransmitter Degradation: The rate at which neurotransmitters are broken down or reabsorbed in the synaptic cleft also plays a role.
