What Conditions Can Cause NRBCs to Appear in Peripheral Blood?
Severe anemia: Conditions like thalassemia and sickle cell disease can cause NRBCs to appear in the peripheral blood due to increased marrow activity. Bone marrow disorders: Diseases such as myelofibrosis or leukemia can disrupt normal erythropoiesis, leading to the release of immature cells. Hypoxia: Low oxygen levels can stimulate the bone marrow to produce and release more immature red blood cells. Hemolytic disease of the newborn: Conditions like erythroblastosis fetalis can result in the presence of NRBCs.
