What Challenges Exist in the Development of HAT Inhibitors?
Despite their promise, there are significant challenges in the development of HAT inhibitors. One major challenge is specificity; many HAT inhibitors can affect multiple types of HAT enzymes or even other acetyltransferases, leading to off-target effects. Another challenge is the delivery of these inhibitors to specific tissues or cells without causing systemic toxicity. Researchers are actively working on improving the specificity and delivery mechanisms of HAT inhibitors to overcome these obstacles.
