Several factors contribute to core sampling bias, including:
Tissue heterogeneity: Variability within a tissue can result in sampling areas that are not representative of the entire specimen. Sampling technique: Inconsistent or improper use of biopsy needles and other tools can lead to biased samples. Specimen handling: Mismanagement during transportation, fixation, or processing can affect the quality and representativeness of the core sample. Pathologist skill: Expertise and experience of the pathologist play a crucial role in selecting representative core samples.
