Congenital hypothyroidism can be caused by several factors, including:
- Genetic Mutations: Mutations in genes involved in thyroid hormone synthesis, such as the TSH receptor gene, can lead to congenital hypothyroidism. - Developmental Defects: Abnormal development of the thyroid gland during embryogenesis, such as thyroid agenesis or ectopic thyroid tissue, can result in the condition. - Maternal Factors: Insufficient iodine intake during pregnancy or maternal thyroid disorders can also contribute to congenital hypothyroidism in the newborn.
