1. Fixation: Tissue samples are first fixed using chemical fixatives like formaldehyde. 2. Dehydration: The samples are dehydrated through a graded series of alcohol. 3. Infiltration: The tissue is gradually infiltrated with GMA monomer. 4. Polymerization: The infiltrated tissue is polymerized at a controlled temperature. 5. Sectioning: The solidified block is sectioned using a microtome for microscopic examination.