What are the Pathological Effects of Beta Amyloid Accumulation?
The accumulation of beta amyloid peptides leads to the formation of extracellular amyloid plaques, which are toxic to neurons. These plaques induce oxidative stress, disrupt cell membranes, and interfere with synaptic function. Additionally, beta amyloid peptides can trigger inflammatory responses in the brain, leading to further neuronal damage. Over time, these pathological changes contribute to the cognitive decline observed in Alzheimer's disease patients.
