While IL-17 inhibitors are generally well-tolerated, they can have side effects. Common side effects include upper respiratory infections, headache, and fatigue. More serious but less common side effects can include an increased risk of infections due to the suppression of the immune system, and potential exacerbation of inflammatory bowel disease. Histologically, this could manifest as reduced mucosal immunity in the gastrointestinal tract, making the tissue more susceptible to infections and inflammation.
