What are the Key Cells Involved in Spinal Modulation?
Several cell types play critical roles in spinal modulation:
1. Neurons: Primary afferent neurons transmit sensory information from peripheral receptors to the spinal cord. Interneurons within the dorsal horn modulate these signals before they are relayed to the brain. 2. Glial Cells: Astrocytes and microglia are essential for maintaining homeostasis and modulating synaptic activity. They can release cytokines and other signaling molecules that influence neuronal function. 3. Ependymal Cells: These cells line the central canal and are involved in the production and circulation of cerebrospinal fluid, which can affect spinal cord physiology.
