What are the Implications of PGC-1α in Neurobiology?
PGC-1α is also expressed in the brain, where it supports neuronal health. It promotes mitochondrial function and antioxidant defense mechanisms, protecting neurons from oxidative stress and neurodegenerative conditions. Alterations in PGC-1α activity have been linked to neurodegenerative diseases such as Parkinson's and Alzheimer's.
