Dysregulation of MRFs can lead to significant implications in muscle development and function. For example, mutations in MyoD or Myf5 can result in congenital myopathies, characterized by muscle weakness and developmental delays. Overexpression or aberrant activation of MRFs can also contribute to the formation of muscle tumors, such as rhabdomyosarcoma. Understanding the regulation of MRFs is therefore crucial for developing targeted therapies for muscle-related disorders.
