What are the Histological Features of Specific Coagulopathies?
Hemophilia A: Histologically, there is often an absence or a significant reduction of factor VIII in the blood. In tissues, this may manifest as prolonged bleeding and poor wound healing. Von Willebrand Disease: Characterized by the deficiency or dysfunction of von Willebrand factor, which is crucial for platelet adhesion. Histological examination may show abnormal platelet clumping and prolonged bleeding times. Thrombophilia: Conditions like Factor V Leiden mutation lead to increased clot formation. Histologically, this can be observed as excessive thrombus formation in blood vessels. Disseminated Intravascular Coagulation (DIC): This condition shows widespread microthrombi in multiple organs, which can be visualized using fibrin stains in tissue sections.
