What are the Histological Features of Primary Tumors?
Primary tumors exhibit several histological features that differentiate them from normal tissues. These include:
- Cellular Atypia: Tumor cells often appear abnormal in shape, size, and organization. - Increased Mitotic Activity: A higher number of cells in mitosis indicates rapid cell division. - Loss of Differentiation: Tumor cells may lose the specialized characteristics of the cells from which they originated. - Necrosis: Areas of cell death due to insufficient blood supply are common in larger tumors. - Stromal Reaction: The connective tissue framework (stroma) may change, showing increased fibrosis or inflammatory cells.
