What are the Histological Features of Organ Rejection?
Organ rejection can manifest in different histological features depending on the type of rejection: - Acute Cellular Rejection: Characterized by lymphocytic infiltration, tubulitis, and endothelialitis in the affected organ. - Antibody-Mediated Rejection: Identified by the presence of donor-specific antibodies, complement deposition (C4d), and neutrophilic infiltration. - Chronic Rejection: Marked by progressive fibrosis, vascular changes, and atrophy of the parenchymal tissue.
