What are the Histological Features of JAK2 Mutation-Associated Disorders?
JAK2 mutations are often linked to myeloproliferative neoplasms (MPNs) such as Polycythemia Vera (PV), Essential Thrombocythemia (ET), and Primary Myelofibrosis (PMF). In histological samples, PV may show increased red blood cell mass and hypercellularity of the bone marrow. ET is characterized by an elevated number of platelets, and PMF exhibits fibrosis and abnormal megakaryocytes.
