What are the Histological Changes in Different Organs?
The histological changes due to ischemic damage can vary between different organs:
Heart: Ischemic damage in the heart, often due to a myocardial infarction, shows coagulation necrosis, loss of nuclei, and infiltration by neutrophils. Brain: In the brain, ischemia leads to liquefactive necrosis, where the tissue becomes soft and is eventually phagocytosed by microglial cells. Liver: The liver shows centrilobular necrosis due to its unique blood supply, with hepatocyte death around the central vein. Kidney: In the kidneys, ischemic injury primarily affects the proximal tubular cells, leading to acute tubular necrosis.
