What are the Different Types of Aminoacyl tRNA Synthetases?
Aminoacyl tRNA synthetases can be broadly classified into two classes based on their structural and functional characteristics:
1. Class I Synthetases: These enzymes generally attach the amino acid to the 2'-OH group of the tRNA's terminal adenine before the amino acid is transesterified to the 3'-OH group. 2. Class II Synthetases: These enzymes directly attach the amino acid to the 3'-OH group of the terminal adenine.
Each class has unique structural motifs that facilitate the binding of the amino acid and tRNA, and they often function as multimers (e.g., dimers or tetramers).
