What are the Clinical Implications of Abnormal Heme Function?
Abnormalities in heme synthesis or function can lead to various clinical conditions. For instance, defects in heme synthesis enzymes can lead to porphyrias, a group of disorders characterized by the accumulation of porphyrin precursors. Abnormalities in hemoglobin, such as those seen in sickle cell anemia or thalassemia, can lead to significant clinical consequences due to impaired oxygen transport.
