What Are the Challenges of Gene Targeting in Histology?
Despite its potential, gene targeting in histology faces several challenges:
Efficiency: Achieving high efficiency in gene targeting, especially in primary cells and tissues, can be difficult. Off-target Effects: Unintended modifications at other genomic locations can lead to erroneous interpretations. Delivery: Efficiently delivering gene-editing tools to specific tissues remains a significant hurdle. Ethical Concerns: The manipulation of genes, particularly in humans, raises ethical issues that must be carefully considered.
