The CNS has limited regenerative capacity due to several factors:
1. Inhibitory Environment: The presence of inhibitory molecules like [Nogo-A](href), myelin-associated glycoprotein (MAG), and chondroitin sulfate proteoglycans (CSPGs) impedes axonal growth. 2. Glial Scar Formation: While the glial scar isolates the injury, it also creates a physical and biochemical barrier to axonal regrowth. 3. Neuronal Death: The loss of neurons and their complex connections can make functional recovery challenging.
