What are the Cellular Changes Associated with Hypoxia?
Under hypoxic conditions, cells undergo several adaptive changes to survive. These include upregulation of HIF-1, which activates the expression of genes involved in increasing oxygen delivery and facilitating metabolic adaptation. Other changes include increased glycolysis, angiogenesis, and the production of erythropoietin. Prolonged hypoxia can lead to cellular injury and death through mechanisms such as necrosis or apoptosis.
