What are some examples of GTPase-related diseases?
Mutations and dysregulation of GTPases are implicated in various diseases. For instance:
Ras mutations are commonly found in various cancers, leading to uncontrolled cell proliferation. Rho GTPases are linked to cardiovascular diseases due to their role in endothelial cell function and vascular remodeling. Rab GTPases are associated with neurological disorders, including Alzheimer's disease, due to their role in vesicle trafficking and synaptic function.
