What are some clinical implications of MHC Class II?
Variations in MHC Class II genes are associated with susceptibility to various autoimmune diseases such as rheumatoid arthritis, type 1 diabetes, and multiple sclerosis. Furthermore, MHC Class II molecules are critical in transplantation immunology, as mismatched MHC molecules can lead to graft rejection. Understanding MHC Class II interactions is therefore pivotal for both disease management and therapeutic interventions.
