Lamin B proteins are essential components of the nuclear lamina, a dense fibrillar network located inside the nucleus of eukaryotic cells. These proteins belong to the family of intermediate filament proteins and play a crucial role in maintaining the structural integrity of the nuclear envelope. Lamin B is encoded by two distinct genes, LMNB1 and LMNB2, which give rise to Lamin B1 and Lamin B2, respectively.