Several key features in tissue samples can provide diagnostic clues:
Cell Shape and Size: Abnormalities in cell shape and size, known as pleomorphism, can indicate malignancy. Nuclear Features: Changes in nuclear size, shape, and chromatin pattern, such as hyperchromasia and nuclear atypia, are significant in diagnosing cancers. Cellular Arrangement: The arrangement and organization of cells in tissues, such as the formation of glandular structures or sheets, can help identify the tissue of origin. Staining Properties: The use of different stains, like Hematoxylin and Eosin (H&E), can highlight specific tissue components and cellular details.
