AIM2-like receptors (ALRs) are a family of cytosolic receptors that play a critical role in the innate immune response. They are part of the larger class of pattern recognition receptors (PRRs) that detect pathogen-associated molecular patterns (PAMPs) and damage-associated molecular patterns (DAMPs). ALRs, including the well-studied AIM2 and IFI16, are essential in recognizing microbial DNA and initiating inflammatory responses.
