Minimizing sampling bias involves several strategies:
Random Sampling: Ensuring that tissue samples are selected randomly can help to provide a more representative sample of the population. Blinded Analysis: Having pathologists analyze samples without knowing the clinical context can reduce observer bias. Standardized Protocols: Using standardized and well-validated protocols for tissue collection, fixation, and processing can help to minimize variability and artifacts. Multiple Sections: Examining multiple sections from different areas of the tissue can provide a more comprehensive view and reduce the impact of heterogeneity.
