Adjusting the blade angle involves manipulating the blade holder on the microtome. Most modern microtomes come with a built-in mechanism to adjust the angle. Here are the steps:
Read the microtome manual to understand the specific adjustment mechanism. Loosen the screws or knobs securing the blade holder. Adjust the holder to the desired angle, usually indicated on a scale. Secure the screws or knobs to lock the blade holder in place. Test the angle by cutting a few practice sections and make further adjustments if necessary.
