Defining the Population: Identify the entire population of tissue sections or cells from which the sample will be drawn. Determining Sample Size: Calculate the number of samples needed to achieve statistical significance, often using formulas or software. Random Selection: Use random number generators or software to select the samples, ensuring each section or cell has an equal chance of being chosen. Preparation and Analysis: Prepare the selected tissue sections for analysis, which may involve staining, sectioning, and imaging.