The process involves several steps: 1. Sample Collection: Tissue samples are obtained through biopsy or surgical resection. 2. Tissue Processing: Samples are fixed, embedded in paraffin, sectioned, and stained. 3. Microscopic Examination: Pathologists examine the stained tissue sections under a microscope. 4. Criteria Evaluation: Grading is based on specific histological criteria, such as cellular atypia, mitotic activity, and architectural pattern.
