The histological grade is determined by evaluating several factors:
Cell Differentiation: How similar or different the cancer cells are compared to normal cells. Mitotic Rate: The number of cells undergoing division. A higher mitotic rate indicates a more aggressive tumor. Nuclear Pleomorphism: The variability in the size and shape of the cell nuclei. Greater variability often corresponds to a higher grade. Architectural Patterns: The organization and structure of the tumor tissue.
