In histology, differentiation is studied through various techniques, including: - Histological staining: Different stains highlight specific cellular components, allowing researchers to observe the structural changes associated with differentiation. - Immunohistochemistry: This technique uses antibodies to detect specific proteins, helping identify markers of differentiation. - In situ hybridization: A method for detecting specific nucleic acid sequences within tissues, providing insights into gene expression patterns. - Microscopy: Advanced imaging techniques, such as electron microscopy, offer detailed views of cellular architecture and differentiation processes.