Diagnosis of dermatitis herpetiformis typically involves a combination of clinical evaluation, histological examination, and immunopathological techniques. A skin biopsy taken from the perilesional area (normal-appearing skin adjacent to a lesion) is often used. The histological examination may reveal the characteristic neutrophilic abscesses at the tips of dermal papillae. Direct immunofluorescence is crucial as it detects IgA deposits in a granular pattern along the dermoepidermal junction.
