Histologists study antigenic variation using various techniques:
1. Immunohistochemistry (IHC): This technique involves using antibodies to detect specific antigens in tissue sections, allowing the visualization of antigenic variation at the cellular level. 2. Fluorescence Microscopy: Tagged antibodies with fluorescent markers can be used to observe changes in antigenic profiles under a microscope. 3. Molecular Techniques: Techniques such as polymerase chain reaction (PCR) and sequencing are used to identify genetic changes responsible for antigenic variation.
