OxLDL plays a key role in the initiation and progression of atherosclerotic lesions. Once oxidized, LDL is more readily taken up by macrophages via scavenger receptors. This leads to the formation of foam cells, which are lipid-laden macrophages that accumulate within the arterial walls. Foam cells contribute to the development of fatty streaks, which are the earliest visible lesions in atherosclerosis.
