How does myocardial infarction appear histologically?
Myocardial infarction (heart attack) results from the occlusion of coronary arteries, leading to ischemia and necrosis of myocardial tissue. Early histological changes include coagulative necrosis, characterized by eosinophilic cytoplasm and loss of nuclei. Within 24-48 hours, neutrophils infiltrate the tissue. Over the following days to weeks, macrophages remove necrotic debris, and granulation tissue forms, eventually leading to scar formation.
