Intravasation occurs through a series of coordinated steps involving the interaction of cancer cells with the microenvironment and the vascular endothelium. Key processes include the degradation of the extracellular matrix, changes in cell adhesion, and the dynamic remodeling of the cytoskeleton. Enzymes such as Matrix Metalloproteinases (MMPs) play a vital role in breaking down the extracellular matrix, facilitating the migration of cancer cells towards and through the vessel walls.
