Increased permeability can occur through various mechanisms. One common cause is the disruption of the endothelial cells that line blood vessels. These cells usually form tight junctions, but during inflammation, cytokines like histamines and bradykinins can loosen these junctions. Another mechanism involves the reorganization of the cytoskeleton within these cells, further compromising the barrier. Additionally, increased permeability can be induced by the degradation of the extracellular matrix, which provides structural support to tissues.
