How Does Erythropoietin Affect the Bone Marrow Histology?
In response to increased levels of EPO, the bone marrow histology shows a higher concentration of erythroid progenitors. The erythroblastic islands, which consist of a central macrophage surrounded by developing erythroblasts, become more prominent. There is also an overall increase in the cellularity of the bone marrow, reflecting enhanced erythropoietic activity.
