How Does Cyclin D Interact with Other Cell Cycle Regulators?
Cyclin D interacts with various cell cycle regulators to control the G1/S transition. It forms complexes with CDK4/6, which then phosphorylate the retinoblastoma protein (Rb). Phosphorylated Rb releases E2F transcription factors, which promote the expression of genes required for DNA synthesis. This interaction underscores the importance of tightly regulated Cyclin D activity for maintaining normal cell cycle progression.
