Topical corticosteroids exert their effects by binding to glucocorticoid receptors in the skin cells. This binding initiates a cascade of events that lead to the suppression of inflammatory pathways. Specifically, they inhibit the production of inflammatory mediators like cytokines and prostaglandins, reduce the migration of immune cells to the site of inflammation, and stabilize lysosomal membranes. These actions collectively decrease redness, swelling, and itching associated with inflammatory skin conditions.
