Aberrant glycosylation can lead to various diseases:
1. Cancer: Changes in glycosylation patterns can affect cell adhesion, migration, and immune recognition, contributing to tumor progression and metastasis.
2. Diabetes: Excess glucose can modify proteins through non-enzymatic glycation, leading to complications such as nephropathy and retinopathy.
3. Congenital Disorders: Genetic defects in glycosylation enzymes can result in congenital disorders of glycosylation, affecting multiple organ systems.
