How do sampling and representativeness impact histological studies?
The accuracy of histological analysis depends on the representativeness of the tissue sample. Biopsies and tissue sections may not capture the heterogeneity of the entire organ or lesion, leading to sampling bias. This can be particularly problematic in cancer diagnosis, where tumor heterogeneity is common. Additionally, the small size of biopsy samples may limit the ability to perform multiple analyses on the same specimen.
