The development of pre B cells involves multiple stages:
Pro-B Cell Stage: Cells undergo heavy chain gene rearrangement. Pre-B Cell Stage: Successful heavy chain rearrangement leads to the expression of the pre-BCR. Immature B Cell Stage: Cells undergo light chain rearrangement and express a complete B cell receptor (BCR).
Each stage is marked by specific gene rearrangements and expression of particular cell surface proteins.
