How do Osteoclasts Interact with Other Bone Cells?
Osteoclasts interact closely with osteoblasts and osteocytes. Osteoblasts produce RANKL and M-CSF, which are essential for osteoclast differentiation and activation. Osteocytes, which are mature bone cells embedded within the bone matrix, can also influence osteoclast activity through the secretion of signaling molecules like sclerostin. This intricate network of cell interactions ensures coordinated bone remodeling.
