Integrins play a pivotal role in cell-matrix adhesion by acting as a bridge between the ECM and the intracellular cytoskeleton. They exist as heterodimers composed of α and β subunits. Upon binding to ECM components like fibronectin or laminin, integrins undergo conformational changes that activate intracellular signaling pathways. This activation facilitates various cellular processes such as migration, proliferation, and survival.
