Immunosuppressive therapies generally function by inhibiting the activation or proliferation of T cells and other immune components. This can involve the use of corticosteroids, calcineurin inhibitors, mTOR inhibitors, and monoclonal antibodies. For instance, corticosteroids reduce inflammation by decreasing the expression of pro-inflammatory cytokines and adhesion molecules, while calcineurin inhibitors like cyclosporine and tacrolimus inhibit T-cell activation by blocking the calcineurin pathway.
