Cell differentiation in limb development is marked by the transformation of mesenchymal cells into various specialized cell types, including chondrocytes, osteoblasts, myoblasts, and fibroblasts. The process of chondrogenesis begins with the condensation of mesenchymal cells, which then differentiate into chondrocytes and form cartilage models of the future bones. Osteogenesis follows, where osteoblasts replace the cartilage with bone tissue. Muscle formation involves the differentiation of myoblasts into mature muscle fibers.
