Cell communication is fundamental for the coordination of activities in multicellular organisms. Cells communicate through chemical signals, such as hormones and neurotransmitters, which bind to specific receptors on target cells. This signaling can occur via direct cell-to-cell contact, or through the release of signaling molecules into the extracellular space. Histological techniques, such as immunohistochemistry, can be used to visualize these signaling molecules and receptors.